We are excited to announce the publication of our latest research in Communications Biology. This study, led by Dr. Haruaki Yanagisawa, Dr. Yoshihiro Kita, Professor Toshiyuki Oda, and Dr. Masahide Kikkawa, uncovers the intricate structure of the uroplakin complex within the porcine urothelial membrane using cryo-electron microscopy (cryo-EM). This groundbreaking study enhances our understanding of the urothelial permeability barrier and the structural dynamics of membrane proteins, paving the way for future research into cellular motility mechanisms and related diseases.